解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Chloroquine is shown to be a potent inhibitor of cholesterol biosynthesis by isolated rat hepatocytes. Half-maximal inhibition of cholesterogenesis occurs at ca. 10 micro M chloroquine. Chloroquine does not affect fatty acid synthesis by isolated hepatocytes. This suggests that chloroquine acts on the cholesterol bios...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535017
更新日期:1981-06-01 00:00:00
abstract::The effects of 2-hexadecynoic acid on the growth and lipid metabolism of cultured 7288 (HTC) cells have been evaluated. Growth was inhibited by the acetylenic acid: the LD50 was 35-85 microM as determined by two methods at low and high cell densities. Reduced growth did not result from damaged plasma membranes as dete...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534955
更新日期:1981-05-01 00:00:00
abstract::In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-delta-lactone. Two minor and less polar products have now been characterized as 15-iodo-14-hydroxyeicosatrienoic acid, omega-...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535024
更新日期:1981-04-01 00:00:00
abstract::Two electrophoretically different forms of sterol ester hydrolase (EC 3.1.1.13) were obtained from the cytoplasmic extract of the mycelia of Fusarium oxysporum. The entities, estimated at 60,000 (I) and 15,000 (II) molecular weights, were obtained in Sephadex G100 column chromatography of the ammonium sulfate precipit...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535686
更新日期:1981-02-01 00:00:00
abstract::Reproductive tissues from male house and field crickets were investigated for the presence of arachidonic acid. Arachidonic acid was identified by retention behavior on 3 gas liquid chromatographic column systems-SE-30, OV 225, and Silar 10C-and by gas liquid/positive ion chemical ionization mass spectrometry. Arachid...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534928
更新日期:1981-01-01 00:00:00
abstract::Acid cholesteryl ester hydrolase (CEH) activity was assayed in mononuclear cells of patients with symptomatic atherosclerosis (transient ischemic attacks, TIA) and in age-matched controls showing no evidence of atherosclerosis. The acid CEH level of TIA patients was significantly lower than that of controls (1074 +/- ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534317
更新日期:1980-12-01 00:00:00
abstract::Lecithin-cholesterol acyltransferase (LCAT, EC 2.3.1.43) was assayed in vitro in plasma from normal man, rat, rabbit and dog by following the formation of 14C-cholesteryl esters subsequent to labeling the plasma with 14C-cholesterol in vitro. In all species examined, various local anesthetics were found to inhibit LCA...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534370
更新日期:1980-10-01 00:00:00
abstract::Chemical ionization (CI) mass spectra of various natural and synthetic steroids have been studied using methane, isobutane, ammonia, trideuterioammonia and hydroxy anion as reagent gases. The CI spectra of steroids give simple and well characterized ions, which provide information about molicular weight as well as fun...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534029
更新日期:1980-09-01 00:00:00
abstract::Male Sprague-Dawley rats were fed diets for 1 or 16 weeks, containing 20% by weight vegetable oils differing widely in their oleic, linoleic and linolenic acid content. No significant changes were observed in the level of the cardiac lipid classes. The fatty acid composition of the 2 major phospholipids, phosphatidylc...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534015
更新日期:1980-09-01 00:00:00
abstract::Isolated perfused rat lungs liberated fatty acids at a rate of 15 mumol/hr during perfusion of triglyceride-rich medium through the pulmonary vascular bed. About 80% of this activity seemed to result from lipoprotein lipase and 20% to hormone-sensitive lipase. Ventilation of the lungs with cigarette smoke instead of a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534227
更新日期:1980-07-01 00:00:00
abstract::The concentrations of the major neutral lipid and phospholipid classes in the plasma of rats bearing hepatoma 7288CTC were determined at various times after transplantation. The fatty acid composition of each lipid class was also analyzed quantitatively as tumor growth progressed. Generally, most lipid classes exhibit...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534066
更新日期:1980-06-01 00:00:00
abstract::The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The delta 6 and delta 5 desaturases were...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535837
更新日期:1980-04-01 00:00:00
abstract::The effect of apo very low density lipoprotein (apo VLDL) and apoprotein C-II on the phospholipase A1 activity associated with lipoprotein lipase (E.C.3.1.1.3) was studied using purified bovine milk lipoprotein lipase. The enzyme degraded 14C phosphatidylcholine (PC) to 14C 2-acyl lysophosphatidylcholine at a rate of ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02540967
更新日期:1980-03-01 00:00:00
abstract::Strong perturbation of the ultraviolet spectrum of the tyrosines of porcine pancreatic colipase A is observed in the presence of Triton X-100 at concentration above the critical micellar concentration. Spectrophotometric titration of the phenolic groups of the protein shows that the apparent pKa value for two tyrosine...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534109
更新日期:1980-01-01 00:00:00
abstract::Microsomal and myelin membrane fractions were prepared from the brains of warm-adapted (room temperature) and hibernating Syrian Hamsters (Mesocricetus auratus). Ethanolamineglycerophospholipids were isolated and subjected to a fractionation scheme to separate the fatty acids of the plasmenylethanolamine and the phosp...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533441
更新日期:1979-12-01 00:00:00
abstract::The de novo synthesis of choline and ethanolamine phosphoglycerides in brain microsomes from 18 month-old male rats was investigated in vitro by using labeled cytidine-5'-diphosphate choline and cytidine-5'-diphosphate ethanolamine as lipid precursors. The rate of synthesis of the two phospholipid classes was found to...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533507
更新日期:1979-11-01 00:00:00
abstract::A new method of isoelectric focusing (IEF) and pH gradient electrophoresis, using thin layers of agarose gel beads, was devised to investigate chylomicrons and very low density lipoproteins (VLDL). pH gradient stability and cathodal gradient drift were similar to those of polyacrylamide gel IEF, and linearity of gradi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534130
更新日期:1979-10-01 00:00:00
abstract::Developing rat brain has the capacity for either delta 9 or delta 6 desaturation of fatty acids. In liver, evidence supports the existence of separate enzymes for each reaction, but it is not known whether in brain delta 9 or delta 6 desaturation of saturated fatty acids involves distinct enzymes. We have used fatty a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533513
更新日期:1979-09-01 00:00:00
abstract::Hydrolysis of cell envelope phospholipids was demonstrated in cells of both autolytic and nonautolytic strains of Neisseria gonorrhoeae that were labeled during growth in the presence of [3H] acetate. The label incorporated into the cellular phospholipids was located exclusively in the fatty acid acyl side chains. Lab...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533897
更新日期:1979-08-01 00:00:00
abstract::Approximately 20% of the phosphatidylglycerol of the lung tissue of several animals was found to have both fatty acids saturated. Pulmonary washings from the lung of the rabbit and guinea pig had more saturated phosphatidylglycerol than the washed lung tissue. Lung-saturated phosphatidylglycerol was relatively low in ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533529
更新日期:1979-06-01 00:00:00
abstract::De novo synthesis and mitochondrial elongation of fatty acids have been demonstrated in subcellular fractions from hog and human aorta. Microsomal fatty acid elongation has been shown in hog aorta. The activity catalyzing the formation of fatty acids from acetyl and malonyl CoA was associated with a high molecular wei...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533461
更新日期:1979-05-01 00:00:00
abstract::The effect of lecithin on jejunal absorption of fatty acids and octadecenoylglycerol was studied in healthy volunteers with a jejunal perfusion system which excluded pancreatic and biliary secretions from the test segment. Lecithin significantly reduced the absorption of oleic acid (P less than 0.05) and octadecenoylg...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533424
更新日期:1979-04-01 00:00:00
abstract::The effect of 1.7-2.2 mg/day oral phenobarbital over short (1 MO) and long term (6-24 MO) treatment on primary bile acid (BA) secretion, composition, synthesis, pool size, and enterohepatic cycling rates as well as phospholipid (PL) and cholesterol (C) secretion rates and biliary composition was determined in 12 asymp...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533915
更新日期:1979-03-01 00:00:00
abstract::Orally administered dihomo-gamma-linolenic acid (DHLA) is well absorbed in man; it appears in blood after ca. 4 hr first as triglyceride ester and later as phospholipid. After sustained-dosing, DHLA penetrated membrane pools and all phospholipid components but, depending on the dosage, reached a metabolic equilibrium ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533869
更新日期:1979-02-01 00:00:00
abstract::Plant sterols were found by gas liquid chromatography in the sterols of five species of aquatic vertebrates; mackerel (Scomber japonicus), rainbow trout (Salmo gairdnerii), smelt (Osmerus dentex), sardine (Sardinops melanosticta) and chimera (Chimera phantasma). The sterols of chimera liver, sardine flesh and sardine ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533558
更新日期:1979-01-01 00:00:00
abstract::Serum high density lipoprotein is increasingly recognized as a negative risk for cardiovascular disease. The distribution and interrelationship of serum lipids, lipoproteins, anthropometric measurements and blood pressures were determined in some 5,000 children. Children had mean +/- S.D. alpha-lipoprotein cholesterol...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533576
更新日期:1979-01-01 00:00:00
abstract::Studies are reported on the capacity of isolated rat renal papilla (inner medulla) to synthesize and release prostaglandin (PG) E from endogenous and exogenous precursor(s) during development of an essential fatty acid (EFA) deficiency in the rat. Weanling (21-day-old) male Sprague-Dawley rats were fed a fat-free diet...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533845
更新日期:1978-12-01 00:00:00
abstract::Fatty acid compositions of polar lipids and triacylglycerols isolated from eggs of the sea urchin, Arbacia punctulata, were examined before and 15 min after insemination. The main fatty acids present in polar lipids and triacylglycerols were palmitate, palmitoleate, eicosaenoate, arachidonate and eicosapentaenoate, wh...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533484
更新日期:1978-11-01 00:00:00
abstract::The major component of cutin from the fruit of both tomato and papaya, dihydroxypalmitate, is shown to have plain positive rotation and is, therefore, assigned L configuration in analogy to other known hydroxy fatty acids. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533487
更新日期:1978-11-01 00:00:00
abstract::Lipids from bovine optic nerve were analyzed. The total content of 16.5% by weight included 27.2% nonpolar lipids, 26.1% glycolipids, and 46.7% phospholipids by weight. Free cholesterol was the major component of the nonpolar lipid fraction. The cerebrosides, 73.5% of total glycolipids, were separated by thin layer ch...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533745
更新日期:1978-10-01 00:00:00
abstract::An analysis of the phospholipid, cholesterol, and phospholipid fatty acyl composition of isolated plasma membranes of 3T3 and SV3T3 mouse mebryo cells has been performed. The results show that the plasma membrane of SV3T3 cells contain relatively less phosphatidylethanolamine and sphingomyelin and more cholesterol tha...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533741
更新日期:1978-10-01 00:00:00
abstract::In their diversity, speciation, and sheer numerical superiority, few should question that insects are the dominant life-form on earth. Their utilization of the multifunctional isopentenoids to regulate their life processes is equally diverse. To catalog or even summarize the contribution of isopentenoids in the regula...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533754
更新日期:1978-10-01 00:00:00
abstract::Starting at 21 days of age, groups of six rats each were fed a basal Torula yeast diet supplemented with 0.4% L-methionine and varying amounts of vitamin E as dl-alpha tocopherol acetate, selenium as sodium selenite, and with either 10% stripped corn oil, stripped lard, or coconut oil. By 7 wk, pentane production by r...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533708
更新日期:1978-06-01 00:00:00
abstract::The stereochemistry of fat digestion and absorption was investigated in rats with thoracic duct fistulas, after feeding synthetic triacylglycerol or alkyldiacylglycerol. After feeding 1,2-dilauroyl-3-oleoyl-sn-glycerol, dilauroyloleoylglycerol and lauroyldioleoylglycerol were the most abundant chyle triacylglycerols. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533725
更新日期:1978-05-01 00:00:00
abstract::The permeability of an N-oleoyldihydrosphingomyelin bilayer against glycerol was similar to that of a bilayer of phosphatidylcholine with identical effective hydrophobic chain length. Cholesterol at 1:1 molar ratio reduced the permeability, and also reduced the energy of activation of glycerol penetration, an effect n...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533668
更新日期:1978-04-01 00:00:00
abstract::Eighteen-month-old Nebraska strain minipigs were fed diets containing 2% cholesterol and 20% corn oil, lard, or coconut oil for 12 to 18 months. Concentrations of serum total lipid, total cholesterol, and total phospholipid increased 200 to 300% with each diet. Changes in serum concentrations of Sf 20+ and Sf 0-20 lip...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533395
更新日期:1978-03-01 00:00:00
abstract::Two simple methods for the synthesis of phosphatidylcholine (lecithin) isotopically labeled in the methyl group of the choline moiety are described. Phosphatidylcholine is converted to phosphatidyl-ethanolamine by enzymic transphosphatidylation, and this is methylated using either methyl iodide or diazomethane to give...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533373
更新日期:1978-01-01 00:00:00
abstract::[4(-14)C] Cholesterol was administered as an aqueous emulsion with triolein and dry non-fat milk either directly into the upper duodenum or into the ileocaecal junction of lymph duct cannulated rats. Lymph flow rates were similar in the two groups of animals. Whereas ca. 53% of the administered tracer dose of choleste...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533375
更新日期:1978-01-01 00:00:00
abstract::Pulmonary surfactant, the major surface-active component of which in the adult is dipalmitoylglycerophosphocholine, can be obtained by lavaging lungs with physiological saline. We have previously shown that there is an increase in the amount of phosphatidylcholine in fetal rabbit lung lavage during the latter part of ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533333
更新日期:1977-12-01 00:00:00
abstract::Trichloroacetic acid (TCA)-phosphotungstic acid (PTA) precipitation has been used as a faster procedure than dialysis for the isolation of gangliosides, but the TCA-PTA treatment causes striking abnormalities in the thin layer chromatographic mobilities of the gangliosides. However, a normal chromatographic pattern ca...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533321
更新日期:1977-11-01 00:00:00